Last edited by Malagis
Saturday, July 25, 2020 | History

3 edition of Pharmacogenetics found in the catalog.

Pharmacogenetics

William G. Newman

Pharmacogenetics

making cancer treatment safer and more effective

by William G. Newman

  • 125 Want to read
  • 33 Currently reading

Published by Springer in Dordrecht .
Written in English

    Subjects:
  • Drug targeting,
  • Genetics,
  • Cancer,
  • Pharmacogenetics,
  • Antineoplastic agents,
  • Neoplasms,
  • Genetic screening,
  • Genetic Testing,
  • Antineoplastic Agents,
  • Physiological effect,
  • Drug Delivery Systems,
  • Genetic aspects,
  • Metabolism,
  • Drug therapy

  • Edition Notes

    Includes bibliographical references and index.

    StatementWilliam G. Newman, editor
    Classifications
    LC ClassificationsRS431.A64 P43 2010
    The Physical Object
    Paginationxv, 186 p. :
    Number of Pages186
    ID Numbers
    Open LibraryOL25353797M
    ISBN 10904818617X, 9048186188
    ISBN 109789048186174, 9789048186181
    LC Control Number2010922454
    OCLC/WorldCa471803604

    Pharmacogenomics can play an important role in identifying responders and non-responders to medications, avoiding adverse events, and optimizing drug dose. Drug labeling may contain information on. COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle .

    Pharmacogenetics involves variations in drug response due to genetic makeup. The activity of drug-metabolizing enzymes often varies widely among healthy people, making metabolism highly variable. Drug elimination rates vary up to fold. Genetic factors and aging seem to account for most of these variations. Pharmacogenetics is the study of inherited differences in interindividual drug disposition and effects, with the goal of selecting the optimal drug therapy and dosage for each patient. Pharmacogenetics for cancer treatment is very significant, as cancer therapies exhibit severe systemic toxicity and unpredictable : Munindra Ruwali.

    The study of pharmacogenetics and pharmacogenomics focuses on how our genes and complex gene systems influence our response to drugs. Recent progress in clinical therapeutics has led to the discovery of new biomarkers that make it technically easier to . This book provides a conceptual framework for understanding and studying the pharmacogenetics of psychotropic drugs, reviews advances in the field, and describes the established findings. Coverage extends to antipsychotics, antidepressants, mood stabilising, cognitive-enhancing and anxiolytic drugs.


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Pharmacogenetics by William G. Newman Download PDF EPUB FB2

It presents not only the basic principles of pharmacogenetics, but also clinically valuable examples that cover a broad range of specialties and therapeutic areas.

The first section of the Pharmacogenetics book outlines critical concepts in pharmacogenetics and pharmacogenomics, including genetic testing, genotyping technologies, and adverse drug effects/5(2).

The rapidly evolving field of Pharmacogenetics aims at identifying the genetic factors implicated in the inter-individual variation of drug response. These factors could enable patient sub-classification based on their treatment needs thus expediting drug development and promoting personalized, safer and more effective treatments.

This book presents Pharmacogenetics book Cited by: 9. The second edition of this highly regarded book provides a systematic and comprehensive account of the foundations, fundamentals, and futures of the field of pharmacogenetics and serves as introduction to all facets of pharmacogenetics for physicians, pharmacists, epidemiologists and other professionals in the life sciences.

Dr.5/5(2). Clinical Applications of Pharmacogenetics. Clinical Applications of Pharmacogenetics. This book presents Pharmacogenetic examples from a broad spectrum of different drugs, for different diseases, which are representative of different stages of evaluation or application.

It has been designed so as to serve both the unfamiliar reader through. Pharmacogenetics: History and origins. Although early observations of unusual drug reactions based on biochemical individuality were noted in the s, the field of pharmacogenetics was not officially recognized until when the term “pharmacogenetics” was first published by the German physician Friedrich Vogel.

19 This was in response to earlier observations of Cited by: Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time.

It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various. In this chapter, we discuss the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group guidelines, including the writing process, components and recommendations, the application of the guidelines to clinical practice, and guideline dissemination.

this book also focuses on clinical areas with successful. What is pharmacogenomics. Pharmacogenomics is the study of how genes affect a person’s response to drugs. This relatively new field combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop effective, safe medications and doses that will be tailored to a person’s genetic makeup.

He is also a co-author for a book chapter on pharmacogenetics in six consecutive editions of the textbook “Pharmacotherapy: A Pathophysiologic Approach”.

Lam designed and continues to direct a graduate course “Molecular and Pharmacological Basis of Therapeutics” since for the UTHSCSA and the College of Pharmacy at the.

Pharmacogenetics and Individualized Therapy. Editor(s): Anke‐Hilse Maitland‐van der Zee It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics.

The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation. Pharmacogenetics is the science studying the interindividual variability in drug response resulting from genetic factors.

In this context, drug response. Pharmacogenetics Definition Pharmacogenetics is the study of how the actions of and reactions to drugs vary with the patient's genes. Description Genes are the portions of chromosomes that determine many of the traits in every living thing.

In humans, genes influence race, hair and eye color, gender, height, weight, aspects of behavior, and even the. This book will benefit upper-level graduate students in pharmacology, genetics, epidemiology, nursing, and public health, and will serve as a handy reference to pharmacists, epidemiologists, and physicians responsible for the delivery and administration of drugs.

Part I describes the emergence and broad scope of pharmacogenetics from an Reviews: 1. pharmacogenetics will depend on scientific research, but it will also depend on decisions of policy and administration which need to provide a combination of incentives and constraints to give the most productive and just direction to pharmacogenetics.

The main purpose of this report is to encourage constructive thought and discussion about someFile Size: 2MB. Pharmacogenetics is the study of genetic factors influencing responses to drug therapy.

The availability of high-throughput geno-typing technologies has led pharmacoge-netics Author: Gerard Marshall Raj. Get this from a library. Pharmacogenetics. [Wendell W Weber] -- Genes are important modifiers of the human response to drugs, hormones, and toxins.

In this second edition of 'Pharmacogenetics', Weber brings together laboratory methods and epidemiologic studies in. Let me provide a brief history of pharmacogenetics.

Its coming was foreseen by Sir Archibald Garrod 1 in his book ‘Inborn Factors in Diseases’, and in by JBS Haldane, 2 who predicted Cited by: Pharmacogenetics 1st Edition PDF Pharmacogenetics 1st Edition PDF Free Download, Pharmacogenetics 1st Edition PDF, Pharmacogenetics 1st Edition Ebook Content The only source on the subject to offer both an overview and a disease-based approach, this reference text spans the wide array of technical, methodological, regulatory, and ethical issues related to.

• Pharmacogenetics (PGx) is the study of how genetic variation changes an individual’s response to a medication • A single nucleotide polymorphism (SNP) is the most common type of genetic variation • If a SNP affects the function of a gene that codes for a drug metabolizing enzyme or a drug transporter or a drug.

In September this year the Nuffield Council on Bioethics held a meeting to disclose and discuss the main findings of their newly published report on the ethical issues associated with developments in pharmacogenetics research. The basics of pharmacogenetics science is briefly outlined, and then the extent to which the report was successful in Cited by:.

The book covers a spectrum of topics, from the evolution of pharmacogenomics to the clinical application of pharmaco­genetics in the clinical setting, with particular focus on select classes of agents and diseases/conditions; competencies for health care professionals; pharmacogenomics research; and regulatory, ethical, and economic issues.

Individual variability in drug efficacy and drug safety is a major challenge in current clinical practice, drug development, and drug regulation. For more than 5 decades, studies of pharmacogenetics have provided ample examples of causal relations between genotypes and drug response to account for phenotypic variations of clinical importance in drug by: Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics By Simon W.

Lam, Pharm.D., FCCM, BCCCP, BCPS Reviewed by Jeffrey J. Fong, Pharm.D., BCPS; and Mindi Miller, Pharm.D., BCPS ABBREVIATIONS IN THIS CHAPTER AKI Acute kidney injury Cl h Hepatic clearance Cl int Intrinsic clearance C max Maximum concentration CYP Cytochrome P .